自噬是繼凋亡之后,生命科學(xué)最熱門(mén)的研究領(lǐng)域之一,近年來(lái),自噬研究得到了飛速發(fā)展。已經(jīng)有研究表明,細(xì)胞自噬與多種疾病和癌癥的發(fā)生有關(guān),基于自噬研究的抗癌藥物研發(fā)也是當(dāng)前的熱門(mén)。
雖然,目前已經(jīng)報(bào)告了很多因素能誘導(dǎo)細(xì)胞發(fā)生自噬,如饑餓、生長(zhǎng)因子缺乏、微生物感染、細(xì)胞器損傷、蛋白質(zhì)折疊錯(cuò)誤或聚集、DNA損傷、放療、化療等等,但是這一過(guò)程的詳細(xì)的信號(hào)轉(zhuǎn)到通路和網(wǎng)絡(luò)仍未完全闡明,這么多刺激信號(hào)如何傳遞的、哪些自噬蛋白接受信號(hào)、又有哪些自噬蛋白去執(zhí)行等很多問(wèn)題都還在等待進(jìn)一步解答中。為促進(jìn)自噬領(lǐng)域最新研究成果的傳播,推動(dòng)轉(zhuǎn)化醫(yī)學(xué)的發(fā)展,我們舉辦中國(guó)北京第一屆自噬與肝病國(guó)際會(huì)議,將邀請(qǐng)國(guó)內(nèi)外分子生物學(xué)、免疫學(xué)、腫瘤學(xué)、肝病科學(xué)等方面的知名專家、教授,針對(duì)當(dāng)前備受關(guān)注的研究熱點(diǎn)及問(wèn)題開(kāi)展研討,為廣大同行搭建一個(gè)相互溝通交流的平臺(tái),特舉辦中國(guó)北京第一屆自噬與肝病國(guó)際會(huì)議。
一、 日程安排
主辦單位: 首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院,北京市肝病研究所(Capital Medical University, YouAnHospital, Beijing Institute of Hepatology)
會(huì)議主席 Chairs: 陳德喜 Dexi Chen,殷曉鳴(Xiao-Ming Yin )
November 8 全天注冊(cè)registration
November 9
8:00-11:30 Morning session (上午會(huì)議)
Moderators (主持人):
Dexi Chen(陳德喜), Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院,北京市肝病研究所)
James Ou, University of Southern California, USA
8:00-8:15 Ni Li (李寧)
首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院院長(zhǎng),北京市肝病研究所所長(zhǎng)
Opening Remarks
(開(kāi)幕詞)
The Frontier of Autophagy Research-1(自噬研究前沿-1)
8:15-9: 00 John Lemasters
University of South Carolina, USA
Mitophagy: types, initiators and role in mitochondrial quality control
(線粒體自噬: 類型, 啟動(dòng)機(jī)制, 及在線粒體質(zhì)控中的作用)
Theme 1. Role of Autophagy in Hepatic Homeostasis
(主題1.自噬在肝臟穩(wěn)態(tài)平衡中的作用)
9:05-9:50 Dexi Chen (陳德喜)
Capital Medical University, YouAnHospital, Beijing Institute of Hepatology(首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院,北京市肝病研究所)
Autophagy and the liver diseases
(自噬和肝臟疾病)
9:55-10:40 Wen-Xing Ding (丁文興)
University of Kansas Medical Center, Kansas City, Kansas, USA
TFEB-mediated lysosome biogenesis in acute-on-chronic alcohol-induced liver injury
(酒精性肝炎中TFEB介導(dǎo)的溶酶體生成機(jī)制)
10:45-11:30 Wei An (安威)
首都醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院
Mitophagy and liver regeneration
(線粒體自噬與肝再生)
11:30-1:30 Lunch Break
1:30-5:00 Afternoon session (下午會(huì)議)
Moderators (主持人):
Xiao-Ming Yin (殷曉鳴), Indiana University School of Medicine
Feng Ren (任鋒), Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院,北京市肝病研究所)
The Frontier of Autophagy Research-2(自噬研究前沿-2)
1:30-2:15 Li Yu (俞立)
清華大學(xué)生命科學(xué)學(xué)院
Mechanism of autophagic lysosome reformation
(自噬性溶酶體再生之機(jī)理)
Theme 2. Role of Autophagy in Liver Tumorigenesis
(主題2.自噬在肝癌發(fā)生中的作用)
2:20-3:05 Masaaki Komatsu
Niigata University, Japan
Autophagy-specific substrates, p62 and NBR1 serve as drive gene products in hepatocellular carcinoma
(自噬特異性底物p62 和NBR1是肝細(xì)胞癌的驅(qū)動(dòng)性基因產(chǎn)物)
3:10-3:55 Huiguo Ding (丁慧國(guó))
Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院,北京市肝病研究所)
Hepatic stellar cells affect the autophagy of hepatocellular carcinoma cells by H2S and its molecular mechanism
(肝星狀細(xì)胞通過(guò)H2S影響肝癌細(xì)胞自噬的分子機(jī)制)
4:00-4:45 James Ou
University of Southern California, USA
Autophagy and Hepatocarcinogenesis
(自噬和肝細(xì)胞癌的發(fā)生機(jī)制)
4:45-5:00 End of day discussion
November 10
8:00-11:30 Morning session (上午會(huì)議)
Moderators (主持人):
John Lemasters, University of South Carolina, USA
Huiguo Ding (丁慧國(guó)), Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院,北京市肝病研究所)
The Frontier of Autophagy Research-3(自噬研究前沿-3)
8:15-9: 00 Eeva-LissaEskelina
University of Helsinki, Finland
Dissecting phagophore assembly site using 3D electron microscopy
(用3D電子顯微鏡術(shù)分析自噬膜前體形成的位置)
Theme 3. Role of Autophagy in Hepatic Viral Infection
(主題3.自噬在病毒性肝炎中的作用)
9:05-9:50 Zhengdong Zhao (趙振東)
中國(guó)醫(yī)學(xué)科學(xué)院病原所
HCV and autophagy
(乙肝病毒和自噬)
9:55-10:40 Aleem Siddiqui
University of California at San Diego, USA
Mitochondrial dynamics, mitophagy and innate immunity in viral hepatitis
(病毒性肝炎中線粒體動(dòng)態(tài),線粒體自噬和天然免疫的關(guān)系)
10:45-11:30 Ying Shi (石英)
Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院,北京市肝病研究所)
Apotentialstrategy to inhibit HBV replication through reducing hepatocytic autophagy
乙型肝炎病毒誘導(dǎo)的自噬及一種通過(guò)降低肝細(xì)胞自噬抑制HBV復(fù)制的新策略
11:30-1:30 LunchBreak
1:30-5:00 Afternoon session (下午會(huì)議)
Moderators (主持人):
Wen-Xing Ding (丁文興), University of Kansas Medical Center, Kansas City, Kansas, USA
Ying Shi (石英), Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院,北京市肝病研究所)
The Frontier of Autophagy Research-4(自噬研究前沿-4)
1:30-2:15 Xiao-Ming Yin (殷曉鳴)
Indiana University School of Medicine, USA
The homeostatic role of autophagy in preventing liver injury
(自噬在預(yù)防肝損傷中的穩(wěn)態(tài)作用)
Theme 4. Role of Autophagy in Liver Injury
(主題4.自噬在肝臟損傷中的作用)
2:20-3:05 Feng Ren (任鋒)
Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院,北京市肝病研究所)
The Critical role of autophagy in the pathogenesis of liver failure and its molecular regulatory mechanisms
(自噬在肝衰竭病理中的關(guān)鍵作用及分子調(diào)節(jié)機(jī)理)
3:10-3:55 Yu Li (李于)
中國(guó)科學(xué)院營(yíng)養(yǎng)研究所
Finding a target for Berbering in the liver
(尋找小檗堿在肝臟中的靶點(diǎn))
4:00-4:45 Xiuhui Li (李秀慧)
Capital Medical University, YouAnHostpical, Beijing Institute of Hepatology (首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院,北京市肝病研究所)
Role of autophagy in the prevention and treatment of acute liver injury by Chinese Medicine
(自噬在中醫(yī)藥防治急性肝損傷中的作用)
4:50-5:00 DexiChen(陳德喜)
Capital Medical University, YouAnHostpical, Beijing Institute of Hepatology (首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院,北京市肝病研究所)
Closing Remarks
(閉幕詞)
二、 會(huì)議時(shí)間、地點(diǎn):
中國(guó)北京 2017年11月9-10日(11月8日全天報(bào)到)
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